![]() ![]() The presence of WPs decreased antibiotic efficacy against biofilm-resident bacteria and promoted MPO and pro-inflammatory cytokine production in vitro. Bone changes were monitored using microCT scanning. epidermidis-inoculated screw implanted in the presence or absence of WPs, and a subgroup was treated with antibiotics. In the ODRI rodent model, rats ( n = 36) had a sterile or S. epidermidis and WPs, and myeloperoxidase (MPO) and cytokine release were analyzed, respectively. Neutrophils or peripheral blood mononuclear cells (PBMCs) were incubated with or without S. Biofilms grown on WPs were challenged with rifampin and cefazolin (100 µg/mL) to determine antibiotic efficacy. The aim of this study was to assess interactions between wear particles (WPs) and immune cells in vitro and to investigate if WPs affect the severity, or response to antibiotic therapy, of a Staphylococcus epidermidis orthopedic device-related infection (ODRI) in a rodent model. Total joint arthroplasty (TJA) surgeries are common orthopedic procedures, but bacterial infection remains a concern.
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